Patrolman McCarty was killed when a truck hit his Patrol car head on near Hudson on Colorado 6 on January 22, 1946. McCarty was returning to Wray from Denver with Leslie Dale Wells, an automobile dealer. Wells died instantly, and McCarty was taken to Colorado General Hospital where he died two days later. An investigation showed the oncoming truck was on the wrong side of the road and weaving when the accident occurred. The truck driver, John McDougal, was charged with manslaughter.

Trooper Templeton died on October 12, 2007 from injuries sustained while assisting a motorist on October 11, 2007. Trooper Templeton and another trooper were assisting a motorist in the center median of I-76 in Adams County, CO when they were struck by another vehicle.

Deputy Supervisor Gulzow, an original member of the Courtesy Patrol, died of injuries received while directing traffic at Red Rocks near Denver. On June 22, 1941, Gulzow was riding a motorcycle and passing stopped traffic when an automobile suddenly made a left turn in front of him. He was transported to St. Luke's Hospital and died on June 26, 1941, due to the severity of his injuries.

Patrolman Bechtelheimer was the first Colorado State Patrol Officer to be slain in the line of duty. While patroling Highway 85-87 North of Colorado Springs on September 14, 1949, he encountered a green Buick traveling Southbound at a high speed. Before Becktelheimer (Beck) approached Rickard McKenna, the driver, Daniel Valenzuela, the passenger, exited the car and came around the back of the car behind Beck. Beck spun around and struck Valenzuela with his flashlight. Valenzuela shot Beck in the chest and in the left arm. Beck returned to his Patrol car to call for help, before dying of his injuries. The two were apprehended later that evening North of Colorado Springs and were sentenced to life in prison.

Sergeant Rosette was killed near Price Utah, in a collision with two trucks on January 31, 1951. Rosette and Grand Junction Sheriff E. E. Redmon were en route to pick up a prisoner for return to Colorado. They met an Eastbound truck passing another Eastbound truck. The passing truck cut in too soon and struck the other truck, which swerved in front of the oncoming Sheriff's car. The Sheriff was seriously injured, but survived. Rosette was killed instantly.

Patrolmen Gresham and Phillips died instantly on February 2, 1956 when their Patrol car was smashed between two semi trucks seven miles Southeast of Hugo on U.S. 287. The officers had stopped a Southbound truck and were issuing clearance to the driver, seated in the patrol car's back seat. A truck approaching from the rear smashed into the back of the patrol car ramming it into the stopped semi. The patrol car was pushed forward more than 65 feet, and the stopped semi was pushed forward 70 feet with its brakes set. All were killed instantly. The driver had not applied the brakes prior to impact. It was suspected he had fallen asleep.

Patrolmen Gresham and Phillips died instantly on February 2, 1956 when their Patrol car was smashed between two semi trucks seven miles Southeast of Hugo on U.S. 287. The officers had stopped a Southbound truck and were issuing clearance to the driver, seated in the patrol car's back seat. A truck approaching from the rear smashed into the back of the patrol car ramming it into the stopped semi. The patrol car was pushed forward more than 65 feet, and the stopped semi was pushed forward 70 feet with its brakes set. All were killed instantly. The driver had not applied the brakes prior to impact. It was suspected he had fallen asleep.

Patrolman Cahalan was killed in a Patrol car accident seven miles West of Kremmling on September 28, 1957. His patrol car went off the road and down a 50-foot embankment. He may have been forced off the road by an oncoming vehicle, but this was never verified. Cahalan was accompanied by Jack Traux of the State Game and Fish Department. Traux suffered a broken leg and back injuries. He could remember some details prior to the accident, but not what happened during the accident.

Corporal Edstrom was wounded September 19, 1959, during a gun battle with three fugitives from Aztec, New Mexico. The fleeing car crashed through a Durango roadblock on U.S. 550. The chase was terminated when the wanted car went down a dead-end alley. Walter Duncan and Barbara Foster jumped out with their hands up. However, J.L. West ran and Edstrom stopped him as he tried to get into another car. During the ensuing gun battle, Edstrom was hit twice. Captain Garnand and Officer Stephens of the Durango Police Department opened fire, hitting West five times. He died instantly. Edstrom was hospitalized at Mercy Hospital in Durango and died on October 28, 1959.

Lieutenant Short was traveling from his new post in Craig to Castle Rock on July 12, 1961 when he responded to a request for assistance from Colorado Department of Wildlife officer Bob Hoover. Hoover had encountered a parked vehicle occupied by Delmar Dean Spooner. When he saw a rifle, he decided to check the vehicle ownership. Spooner pulled out a Walther P38 handgun and shot Grand County Sheriff Chancy Van Pelt, who also had responded to the scene. Then he shot Short and fired at Hoover. Hoover and Van Pelt survived their injuries, but Short died during surgery. Spooner was spotted two days later by a train crew. He was later sentenced to life imprisonment in the Colorado State Penitentiary.